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. 2022 Oct 19;11(20):3294. doi: 10.3390/cells11203294

Figure 2.

Figure 2

Generation of chemo-drug resistant TNBC. (A) Analysis of the viability of doxorubicin-resistant MDA-MB-231 (upper) and paclitaxel-resistant MDA-MB-231 (lower) cells treated with 5 nM of doxorubicin or 2 nM of paclitaxel for 7 days compared with parental MDA-MB-231 cells, assessed using MTT assays. (B) Analysis of growth of doxorubicin-resistant MDA-MB-231 (upper) and paclitaxel-resistant MDA-MB-231 (lower) cells compared with parental MDA-MB-231 cells treated with a serial dose of doxorubicin and paclitaxel, assessed performing colony formation assays. (C) Quantitative analysis for colony formation assays in MDA-MB-231-DoxR and MDA-MB-231-PtxR cells treated with doxorubicin or paclitaxel, respectively. Data are represented as the mean ± SEM for biological triplicate experiments. * p < 0.05, compared with the results for control cells.