FIG 1.

Hypervirulence of a codY null mutant requires saeRS and hla. (A) BALB/c mice were infected subcutaneously with one of six S. aureus strains, and the size of dermonecrotic lesions was quantified for 7 days postinfection. Data for saeR, codY saeR, hla, and codY hla strains were indistinguishable at this scale and not statistically significantly different from each other and so are plotted using the same color. Lines represent means from 12 mice ± standard deviation. ***, P < 0.001, two-way ANOVA with repeated measures with Tukey post hoc test relative to wildtype (WT) each day. (B) Lesion CFU count 7 days postinfection. ***, P < 0.001, ANOVA with Tukey post hoc test relative to WT.