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. 2022 Oct 20;14(20):5135. doi: 10.3390/cancers14205135

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The diverse molecular impacts of protein interactions with O-GlcNAc cycling enzymes. (a) Classification of reported OGT/OGA binding partners in cancer. The information of OGT and OGA binding partners was from database OGT-PIN (high-stringency interaction proteins) and PINA, respectively. The binding partners were categorized using the databases AnimalTFDB 3.0 [98], KinMap [99], DEPOD [100], UbiBrowser 2.0 [101], UbiNet 2.0 [102], RBP2GO [103], and gene ontology (GO term: cytoskeleton) from DAVID [97]. The venn diagram was generated from http://bioinformatics.psb.ugent.be/webtools/Venn/ (accessed on 15 October 2022). RBP, RNA binding protein; TF, transcription factor; E3, E3 ubiquitin ligase; DUB, deubiquitinase. (b) Different molecular mechanisms underlying the protein interactions with O-GlcNAc cycling enzymes in dysregulating protein functions in cancer cells (OGT is shown as an example).