Figure 5.

The binding orientation of active compounds is shown in the active site of hCA-IX. (A–C) The docked pose of the most active compounds, 7, 3, and 4. (D) The binding modes of all the inhibitors at the active site of hCA-IX. In the active site, zinc is presented as a slate blue sphere, the ligands are depicted in different colors in stick models, the active site residues are shown in pink stick models, and the hydrogen bonds are presented in black lines.