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. 2022 Sep 26;12(5):788–796. doi: 10.3390/clinpract12050082

Figure 4.

Figure 4

Signaling pathway of type III IFN. The receptor is made of two subunits: IFN-28Rα and IL-10R2. Type III IFN binds to the IFN-28Rα receptor which leads to a conformational change, resulting in the addition of IL-10R2. JAK1 and TYK2 then phosphorylate the intracellular domain of IFN-28Rα, allowing STAT to recognize it and bind and form a complex known as ISGF3. This ISGF3 complex moves into the nucleus and bind to the promoter region of ISG, known as ISRE, leading to IFN-stimulated gene products.