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Molecular pathways in iCCA. Inhibitors have been developed for well-known signaling pathways including the Raf/MEK/ERK, PI3K-AKT, and JAK/STAT pathway. AKT: protein kinase B; FGFR: fibroblast growth factor; HER2: epidermal growth factor receptor 2; JAK: janus kinase; mTOR: mammalian target of rapamycin; PI3K: phosphoinositide 3-kinase. NTRK: neurotrophic receptor tyrosine kinase.
