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. 2022 Sep 27;9(10):1473. doi: 10.3390/children9101473

Table 2.

Number of hypersensitivity reactions to intravenous iron formulations according to the U.S. Food and Drug Administration Adverse Event Reporting System database that included all of the population aged over 6 years [10] and incidence rate of anaphylaxis according to insurance claims from Medicare, U.S., in older people [11].

Hypersensitivity Reaction (n) [10] Anaphylactic Reaction (n) [10] Deaths (n) [10] Adjusted Incidence Rate of Anaphylaxis in 10,000 First Administrations [11]
Iron dextrans 57 22 4 9.8
Iron sucrose 212 43 7 1.2
Ferumoxytol 196 67 23 4
Ferric carboxymaltose 401 51 1 0.8