Table 3.
Single locus analysis for the association between SOD2 rs4880 and AD, in co-dominant, dominant, recessive, over-dominant, and log-additive modes.
| Unadjusted Analysis | Adjusted Analysis | ||||
|---|---|---|---|---|---|
| Mode | Genotype | OR (95%CI) | p-Value | OR (95%CI) | p-Value |
| Codominant | T/T | 1.00 | 0.59 | 1.00 | 0.53 |
| C/T | 1.10 (0.75–1.60) | 1.05 (0.71–1.55) | |||
| C/C | 0.90 (0.58–1.40) | 0.84 (0.53–1.33) | |||
| Dominant | T/T | 1.00 | 0.87 | 1.00 | 0.92 |
| C/T-C/C | 1.03 (0.72–1.47) | 0.98 (0.68–1.42) | |||
| Recessive | T/T-C/T | 1.00 | 0.37 | 1.00 | 0.27 |
| C/C | 0.85 (0.59–1.22) | 0.81 (0.56–1.18) | |||
| Overdominant | T/T-C/C | 1.00 | 0.36 | 1.00 | 0.4 |
| C/T | 1.15 (0.85–1.57) | 1.15 (0.83–1.58) | |||
| Log-additive | - | 0.95 (0.76–1.19) | 0.65 | 0.92 (0.73–1.15) | 0.47 |
SOD2, Superoxide dismutase 2; AD, Alzheimer’s Disease; CI, confidence interval; OR, odds ratio. Adjustment was made for sex as a categorical variable.