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. 2022 Sep 25;29(10):6933–6946. doi: 10.3390/curroncol29100545

Figure 1.

Figure 1

FOXO1 expression in MDS with different clinical features. (A) showed that the higher neutrophil count group had increased FOXO1 expression than lower neutrophil count group in MDS. (B) showed a significant decrease in FOXO1 expression with an increase in MDS bone marrow blasts, and the expression of FOXO1 in bone marrow blasts greater than 10% was significantly decreased in MDS patients. (C) showed that MDS patients with very good, good karyotypes had significantly higher FOXO1 expression than patients with poor, very poor karyotypes. (D) showed that FOXO1 expression was significantly higher in MDS-MLD patients than in MDS-EB1 and EB2 patients. (E,F) showed FOXO1 expression in lower-risk MDS was significantly higher than higher-risk MDS patients according to IPSSR and WPSS scoring systems. * means p < 0.05, ** means p < 0.01, *** means p < 0.001, NS means no significance. Abbreviations: Neu, neutrophil; WHO, World Health Organization; MDS-SLD, MDS-single lineage dysplasia; MDS-MLD, MDS-multilineage dysplasia; MDS-EB1, MDS-excess blasts-1; MDS-EB2, MDS-excess blasts-2; WPSS, WHO classification-based Prognostic Scoring System; IPSSR, Revised International Prognostic Scoring System.