Table 2.
Clinical, biochemical, and staging characteristics of the enrolled population (n = 58), categorized according to HCC recurrence. Abbreviations: BCLC: Barcelona Clinic Liver Cancer; AST: aspartate aminotransferase; ALT: alanine aminotransferase; GGT: γ-glutamyl transferase; ALP: alkaline phosphatase; INR: international normalized ration; AFP: α-fetoprotein; PLR: platelet/lymphocyte ratio; LMR: lymphocytes/monocytes ratio; NLR: neutrophils/lymphocytes ratio; NS: not significant; NA: not applicable.
| Variables | Altogether N = 58 |
Without HCC Recurrence N = 34 |
HCC Recurrence N = 24 |
Significance |
|---|---|---|---|---|
| Gender, Male | 48 (82.8%) | 26 (76.5%) | 22 (91.7%) | p = 0.032 |
| Age, years | 70 (65; 77) | 70 (65; 78) | 70 (65; 76) | NS |
| Etiology, Viral | 27 (46.6%) | 14 (41.2%) | 13 (54.2%) | NS |
| Presence of Liver Cirrhosis | 51 (87.9%) | 28 (82.4%) | 23 (67.6%) | NS |
| Number of Nodules, number | 1 (55, 94.2%) 2 (3, 6.8%) |
1 (33, 97%) 2 (1, 3%) |
1 (22, 91.7%) 2 (2, 8.3%) |
NS |
| Nodule Maximum Diameter, mm | 22 (15; 30) | 18 (13; 23.5) | 33 (24; 48) | p < 0.0001 |
| BCLC | ||||
| Stage 0 Stage A |
28 (48.3%) 30 (51.7%) |
17 (50%) 17 (50%) |
11 (45.8%) 13 (54.2%) |
NS |
| AST, IU/L | 25.5 (22; 37) | 25 (22; 36) | 28 (21; 65) | NS |
| ALT, IU/L | 22 (17; 35) | 20.5 (15; 33) | 25 (18; 59) | NS |
| ALP, IU/L | 92 (75; 112) | 94 (77; 114) | 84 (75; 101) | NS |
| GGT, IU/L | 56 (38; 112) | 50 (30; 111) | 60 (48.5; 128) | NS |
| Total Bilirubin, mg/dL | 0.89 (0.62; 1.20) | 0.75 (0.58; 1.15) | 0.93 (0.75; 1.21) | NS |
| Albumin, g/dL | 4.1 (3.8; 4.4) | 4.2 (3.82; 4.4) | 4.1 (3.8; 4.5) | NS |
| Platelet Count, × 103 cell/mm3 | 123 (98; 171) | 143 (107; 205) | 111.5 (92; 129) | p = 0.03 |
| Creatinine, mg/dL | 0.83 (0.74; 0.93) | 0.87 (0.78; 0.94) | 0.80 (0.71; 0.92) | NS |
| INR | 1.1 (1.03; 1.12) | 1.05 (1; 1.11) | 1.08 (1.03; 1.13) | NS |
| AFP, ng/mL | 4.4 (2.6; 6.9) | 4 (2.5; 6.35) | 4.7 (3.55; 7.37) | NS |
| PLR | 98.5 (86; 133.5) | 103.5 (89.5; 148) | 92 (78.5; 114) | p = 0.026 |
| LMR | 2.9 (2.1; 3.8) | 2.6 (2; 3.7) | 3.2 (2.7; 4.2) | p = 0.041 |
| NLR | 2.3 (1.8; 3.2) | 2.6 (1.9; 3.4) | 1.9 (1.5; 2.8) | p = 0.043 |
| Child–Pugh | ||||
| A5 A6 A7 |
44 (75.9%) 13 (22.4%) 1 (1.7%) |
24 (70.6%) 10 (29.4%) 0 (0%) |
20 (83.3%) 3 (12.5%) 1 (4.2%) |
NA |
| MELD | 7 (7; 9) | 7 (7; 10) | 7 (7; 9) | NS |