Figure 2.

TP53 structure and mutation distribution (%) within the DNA-binding domain (DBD). The frequency of each mutation in all cancers based on the p53 database (www.p53.fr) is indicated for the DBD of TP53. Amino acid positions are indicated below the domains. Five TP53 hotspot mutation sites are further indicated with codon numbers above the bars. TA = transactivation domain; PRR = proline-rich region; DBD = DNA-binding domain; TD = tetramerization domain; CTD = carboxyl terminal regulatory domain.