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. 2022 Oct 20;14(20):5150. doi: 10.3390/cancers14205150

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Characterization of G-M55 as a bimodal contrast agent. (a) Relaxometry measurement of naked (M55; blue line) and coated (G-M55; red line) nanoparticles, through the MPI RELAX module. This measurement enabled quantification of signal efficiency and of the resolution given by the tracer. (b) Plot of transverse relaxation rate (1/T2) vs. Fe concentration in water-dispersed G-M55 phantoms, at 25 °C. The slope of the fitting straight line (53.20 mM⁻¹s⁻¹) represents the transverse relaxivity coefficient (r₂). (c) T2w MR images of phantoms, containing decreasing concentrations of G-M55.