Table 4.
Mechanistic Roles of Sirtuins (SIRT1–7) Regulation by miRNAs in Prostate Cancer.
| Sirtuins | Regulatory microRNA | Function | References |
|---|---|---|---|
| SIRT1 | miR-34a | Reduces growth and chemoresistance of prostate cancer | [213] |
| SIRT1 | miR-204 | Enhances docetaxel-induced apoptosis of prostate cancer | [214] |
| SIRT1 | miR-138-5p | Inhibits proliferation and lipid metabolism of prostate cancer | [215] |
| SIRT1 | miR-204 | Enhances doxorubicin-induced mitochondrial-mediated apoptosis of prostate cancer | [216] |
| SIRT1 | miR-449a | Suppresses invasiveness of prostate cancer | [217] |
| SIRT1 | miR-212 | Inhibits starvation- and SIRT1-induced autophagy of prostate cancer | [218] |
| SIRT1 | miR-34a | Inhibits proliferation of prostate cancer | [219] |
| SIRT2 | Not known | Not Known | Not Known |
| SIRT3 | Not Known | Not Known | Not Known |
| SIRT4 | Not Known | Not Known | Not Known |
| SIRT5 | Not Known | Not Known | Not Known |
| SIRT6 | Not Known | Not Known | Not Known |
| SIRT7 | Not Known | Not Known | Not Known |