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Mechanisms of DC tolerance in the tumor microenvironment. It is possible for tumor-derived soluble mediators to functionally tolerate DCs located inside tumor beds, tumor-draining lymph node tissues, or at more distant metastatic sites. This pathway promotes DC-dependent Treg differentiation while suppressing DC-mediated effector T cell responses, which aids in tumor development and progression. Reproduced with permission from [69]. Copyright 2019, Frontiers Media S.A.
