Table 5.
Ref | Year | Double Fusion | ALK-TKIs | Treatment | Response | |
---|---|---|---|---|---|---|
1 | Wu, X. et al. [104] | 2020 | CCNY-ALK ATIC-ALK | Crizotinib | First line | PR > 6 m |
2 | Wu, X. et al. [105] | 2020 | NLRC4-ALK;EML4-ALK | Crizotinib | First line | PFS > 10 m |
3 | Luo, J. et al. [106] | 2019 | PRKCB-ALK; EML4-ALK | Crizotinib Ceritinib |
First line Second line |
PFS: 6 m PFS > 2 m |
4 | Qin, B. et al. [107] | 2019 | BCL11A-ALK; EML4-ALK | Crizotinib | First line | PFS: 13 m |
5 | Lin, H. et al. [108] | 2018 | FBXO11-ALK; EML6-ALK | Crizotinib | Second line | PFS > 11 m |
6 | Yin, J. et al. [109] | 2018 | DYSF-ALK; ITGAV-ALK | Crizotinib | Second line | PFS > 3 m |
7 | Tao, H. et al. [110] | 2022 | ALK-SSH2; EML4-ALK | Crizotinib | First line | PFS: 9 m |
8 | Tao, H. et al. [110] | 2022 | ARID2-ALK; EML4-ALK | Crizotinib | First line | PFS: 12 m |
9 | Guo, J. et al. [111] | 2020 | CDK15-ALK; EML4-ALK | Crizotinib | Second line | PFS: 23 m |
10 | Zeng, H. et al. [68] | 2021 | PDK1-ALK; STRN-ALK | Alectinib | First line | PFS > 11 m |
11 | Zhai, X. et al. [112] | 2022 | ALK-GCA; EML4-ALK | Alectinib | First line | PFS > 20 m |