Table 4.
List of PPAR-γ partial agonists and their significant role in cancer therapeutics.
| PPAR-γ Partial Agonist | Type of Compound | Effect in Disease | Cell Line | Type of Cancer | References |
|---|---|---|---|---|---|
| Deoxyelephantopin | Natural | Apoptosis and cell cycle arrest (G(2)/M) | HeLa | Cervix | [69] |
| Halofenate | SPPAR-γM | Anti-proliferative effects | MM96L | Melanoma | [226] |
| Tetrazanbigen | Sterol isoquinoline derivative | Anti-proliferative effects | HepG2 and A549 | Liver and lung | [220] |
| HydroxyCinnamic Acid Derivatives | p-coumaric acid and ferulic acid | Anti-proliferative effects | K562 | Chronic Myeloid Leukemia | [222] |
| Telmisartan | Angiotensin II (Ang II) receptor blocker | Apoptosis and anti-proliferative effects | Caki-1,T24, LNCaP, PC3, DU-145 and NEC-8 | Renal, bladder, prostate and testicular | [203] |
| Anti-proliferative effects | A549 | Lung | [227] |