Figure 11.

Restraining NF-κB signaling: A promising therapeutic strategy against inflammatory diseases. (A) Signaling to NF-κB is augmented in the setting of inflammatory diseases and may be regulated via multiple pathways. (B) Direct blockade of the receptor or NF-κB may abolish inflammation, compromising the host defense and tissue repair mechanisms. (C) Identification of signaling networks in control of aberrant NF-κB activation and selective targeting of key signaling molecules (alone or in combination) is key to eliminate the detrimental inflammation while maintaining the host defense, tissue repair, and homeostasis functions.