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. 2022 Sep 26;44(10):4447–4471. doi: 10.3390/cimb44100305

Figure 2.

Figure 2

Regulation of angiogenesis via the canonical NF-κB pathway in CRC. The extracellular compounds BAY11-7082, crocin, Q8, and PT inhibit the expression of VEGFA by suppressing the phosphorylation of IκB. While GNA13 promotes angiogenesis through the regulation of chemokines production. AP restrains IL-8 production and angiogenesis by inhibiting the degradation of IκB, then prevents NF-κB from entering the nucleus. SAFB targets the promoter of TAK1 in the nucleus and inhibits angiogenesis. The expression of miR-375 can downregulate MTDH level, leading to the inhibitory effect of IκBα on NF-κB. Q8: IUPAC name (E)-2-(2-quinolin-2-yl-vinyl)-benzene-1,4-diol HCl; AP: Andrographolide; PT: Parthenolide; IKK: IκB kinase complex; SAFB: scaffold attachment factor B; MTDH: metadherin.