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. 2022 Sep 26;44(10):4447–4471. doi: 10.3390/cimb44100305

Figure 4.

Figure 4

Regulation of angiogenesis via the Wnt/β-catenin signaling pathway in CRC. DKK1 acts on LRP5/6. LRP5/6 causes the degradation of β-catenin. SFRPs combine with Wnt3a to inhibit the expression of β-catenin. LncRNA GAS5 reduces the expression of β-catenin, c-Myc, and cyclin D1. MiR-29b downregulates the expression of β-catenin. Vitamin D can activate VDR, and the activated VDR inhibits the expression of c-Myc. SAH-BCL9 dissociates native β-catenin/BCL9 complex and then suppresses Wnt transcription selectively. IL-8 acts on AKT/GSK3β/β-catenin, which promotes the Wnt/β-catenin pathway. TGM2 upregulates the expression of Wnt3a, β-catenin, and cyclin D1. TAMs release IL-1β, which acts on NF-κB/AKT/GSK3β and promotes Wnt signaling. SDF-1 activates CXCR4, which causes the expression of miR-125b and activates the Wnt/β-catenin signaling pathway.