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. 2022 Sep 26;44(10):4447–4471. doi: 10.3390/cimb44100305

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Regulation of angiogenesis via the Notch signaling pathway in CRC. Notch1 is a single transmembrane protein located on the cell surface that interacts with Dll4 and Jagged1 expressed on adjacent cells. As a result, γ-secretase is activated to split Notch to induce NICD into the nucleus. Then, VEGFR3 and HES-1 are upregulated and are involved in subsequent angiogenesis in CRC. As inhibitors of the Notch pathway, ABL001, berberine, and quercetin are considered potential therapeutic agents to inhibit angiogenesis in CRC.