Phycocyanin ameliorates the biochemical indicators of serum in diabetic mice. The levels of triglyceride (TG), total cholesterol (TC), aspartate transaminase (AST), glutamic-pyruvic transaminase (ALT), high-density lipoprotein (HDL), low-density lipoprotein (LDL), and superoxide dismutase (SOD) were detected in the NC, NCPC, T2DM, TLPC, THPC, and T groups. Data are expressed as means ± SD for 12 mice. * (p < 0.05) and ** (p < 0.01) represent groups with significant differences compared with the NC group. # (p < 0.05) and ## (p < 0.01) represent group with significant differences compared with the T2DM group.