Phycocyanin increases the activity of the AKT and AMPK pathway in insulin-resistant SMMC-7721 cells. (A) Western blot analysis of the AKT signaling pathway in the N1, N2, Y1, and Y2 groups. (B) Western blot analysis of the expressions of the AMPKα and IRS proteins in the N1, N2, Y1, and Y2 groups. * (p < 0.05) represent groups with significant differences compared with the N1 group. # (p < 0.05) and ## (p < 0.01) represent groups with significant differences compared with the Y1 group. N1 represents control cells, N2 represents control cells with phycocyanin treatment, Y1 represents insulin-resistant cells, and Y2 represents insulin-resistant cells with phycocyanin treatment.