Table 3.
Correlation of circulating IL‐38 with biomarkers of disease
| Protein ID (full protein name) | Function | Spearman's r | Unadj. p value | Adj. p value |
|---|---|---|---|---|
|
NT‐3 (neurotrophin‐3) |
Nervous system development (GO:0007399) Positive chemotaxis (GO:0050918) |
0.336 | .002 | .008 |
|
TNFRSF9 (TNF receptor superfamily member 9) |
Negative regulation of cell population proliferation (GO:0008285) Tumor necrosis factor‐mediated signalling pathway (GO:0033209) |
0.270 | .008 | .030 |
|
PIgR (polymeric immunoglobulin receptor) |
Mediated by polymeric immunoglobulin receptor (GO:0002415) Fc receptor signalling pathway (GO:0038093) |
0.297 | .009 | .047 |
|
COMP (cartilage oligomeric matrix protein) |
Extracellular matrix organization (GO:0030198) Positive regulation of chondrocyte proliferation (GO:1902732) |
−0.240 | .018 | .053 |
|
CHL1 (neural cell adhesion molecule L1‐like protein) |
Cell adhesion (GO:0007155) Axon guidance (GO:0007411) |
0.229 | .024 | .068 |
|
TNF (tumor necrosis factor) |
Positive regulation of cytokine production involved in inflammatory response (GO:1900017) Positive regulation of fever generation (GO:0031622) |
0.231 | .024 | .072 |
|
SERPINA12 (serpin family A member 12) |
Negative regulation of endopeptidase activity (GO:0010951) | −0.261 | .023 | .088 |
|
CD244 (CD244) |
Adaptive immune response (GO:0002250) Leukocyte migration (GO:0050900) |
0.22 | .032 | .088 |
|
IL10RA (interleukin 10 receptor subunit alpha) |
Interleukin‐10 binding (GO:0019969) | 0.243 | .035 | .095 |
| Negative regulation of autophagy (GO:0010507) | ||||
|
SOD2 (superoxide dismutase 2) |
Superoxide dismutase activity (GO:0004784) Negative regulation of oxidative stress‐induced intrinsic apoptotic signalling pathway (GO:1902176) |
0.252 | .028 | .102 |
|
FABP2 (fatty acid‐binding protein 2) |
Triglyceride catabolic process (GO:0019433) Intestinal lipid absorption (GO:0098856) |
0.252 | .028 | .103 |
Abbreviation: IL, interleukin.