FIGURE 1.

Assay for Transposase‐Accessible Chromatin using sequencing (ATAC‐seq) and in situ chromatin profiling methods are rapidly growing in popularity. Graph shows the number of Google Scholar citations each year using each of the indicated terms (together with “chromatin” to reduce false‐positives), where the number for 2022 has been linearly extrapolated based on statistics through September 17, 2022. Since its introduction in 2007, ChIP‐seq has dominated chromatin profiling, currently with ~10,000 citations per year, but the recent leveling off is likely attributable to the rapidly growing popularity of ATAC‐seq. Based on this metric, CUT&RUN and CUT&Tag, respectively introduced in 2017 and 2019, are growing in popularity at about the same rate as ATAC‐seq during its first 5 years. ATAC‐seq and in situ chromatin profiling are suitable for single‐cell platforms and so are likely to further chip away at the dominance of ChIP‐seq in the future. FAIRE and DamID are respectively alternative chromatin accessibility and chromatin profiling methods.