TABLE 3.

Comparison of different methods tested on the S350 dataset

	Overall		Stabilizing mutations		Destabilizing mutations
Method	σ	r	σ	r	σ	r
BayeStab	1.09	0.75	1.29	0.66	1.37	0.62
DUET	1.31	0.67	1.00	0.65	2.23	0.28
DynaMut2	1.37	0.66	1.16	0.63	2.01	0.38
SDM	1.80	0.52	1.43	0.42	3.12	0.15
mCSM	1.08	0.66	1.01	0.63	2.48	0.31
MAESTRO	1.79	0.55	1.52	0.43	1.37	0.61
I‐mutant	1.75	0.53	1.42	0.42	2.89	0.25