Table 1.

Summary of Childhood Obesity published manuscripts.

Reference Paper	Title	Study Design	Major Finding
Li L 2017, [21]	Identification of key genes and pathways associated with obesity in children	Subcutaneous adipose tissue collected from pediatric obese and lean patients	Matrix metallopeptidase 9 (MMP9) is upregulated in immune system process and has a significant role in child obesity
Jaitlin DA 2019, [22]	Lipid associated macrophages control metabolic homeostasis in a Trem2-dependent manner	Mapping of adipose tissue immune populations in both mice and humans	Identification of associated macrophages subsets with markers and functional pathways associated with adipose tissue and obesity
O’shea D 2019, [23]	Dysregulation of natural killers in obesity	Blood samples collected from obese patients	NK cells have a role in homeostasis and if not functional contribute to pathophysiology of inflammation
Bassols J 2014, [24]	Increased serum Immunoglobulin G (IgG) and Immunoglobulin A (IgA) in overweight children relate to a less favorable metabolic phenotype	Blood from pediatric obese population	Increased circulating IgG and IgA in overweight children are associated with metabolic phenotype
Yang Dh 2021, [25]	Effector memory CD8+ and CD4+ T cell immunity associated with metabolic syndrome in obese children	Blood from pediatric obese population	In obese children, the changes in CD8+ T cells might be related to the morbidity of obesity
Skinner Ac 2010, [26]	Multiple markers of inflammation and weight status: cross-sectional analyses throughout childhood.	Blood samples from pediatric population	Inflammatory markers are strongly and positively associated with increasing weight status in children
Sasaki A 2022, [13]	DNA methylation profiles in the blood of newborn term infants born to mothers with obesity	Newborn blood sample collected by heel stick	DNA methylation modifications were associated with maternal obesity