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New mutation Val63Gly in the ligand-binding domain of IFN-γR1. (a) Sequence of the new mutation boundaries. Italics, amino acids implicated in the binding of IFN-γ to its receptor 28; roman amino acids conserved in murine IFN-γR1 4. (b) Pedigree and SSCP intrafamilial segregation of the Val63Gly mutation compared with a control.
