TABLE 2.

Frequencies of phage resistant clones from samples exposed to either ciprofloxacin, or phages, or their combination in the HFIM during 72 h^a

Bacteria source	Resistance to LUZ19v	Resistance to PAK_P1
Inoculum	1.10−7	6.10−5
HFIM (72 h samples)
Control (n = 1)	8.10−5	<LODc
Ciprofloxacin (n = 2)	1.10−5; 1.10−5	6.10−6; 3.10−6
LUZ19v (n = 2)	5.10−1; 2. 10−1	8.10−5; 1.10−7
PAK_P1 (n = 2)	3.10−7; <LODc	1; 6.10−1
LUZ19v and PAK_P1 (n = 2)	1.10−2; 6.10−3	2.10−1; 8.10−3
Simultaneous combination of ciprofloxacin and phages (n = 2)	NBRb	NBRb
Delayed combination of ciprofloxacin and phages (n = 2)	NBRb	NBRb
Simultaneous combination of ciprofloxacin and phages (n = 2)	1; <LODc	<LODc; 1
Delayed combination of ciprofloxacin and phages (n = 2)	NBRb	NBRb

^aGray lines correspond to experiments performed with an inoculum of 8 log₁₀ CFU/mL.

^bNBR, no bacteria recovered.

^cLOD, limit of detection.