TABLE 4.

Antimicrobial activity of imipenem-relebactam, imipenem and ceftazidime-avibactam (EUCAST criteria) against the carbapenemase-producing Klebsiella spp. isolates recovered during the SUPERIOR and STEP surveillance studies broken down by the carbapenemase type produced

		Imipenem				Imipenem-relebactam				Ceftazidime-avibactam
β-lactamases	ST (no. of isolates)	S + I		R		S		R		S		R
		No.	%	No.	%	No.	%	No.	%	No.	%	No.	%
All carbapenemases (n = 41)		22	53.7	19	46.3	32	78.1	9	21.9	40	97.6	1	2.4
OXA-48a (n = 21)	ST11 (13), ST15 (3), ST215 (2), ST392 (2), ST307 (1)	16	76.2	5	23.8	14	66.7	7	33.3	21	100	0	0
KPC-3b (n = 15)	ST13 (5), ST15 (2), ST231 (2), ST11 (1), ST405 (1), ST4331 (1), ST34 (1), ST45 (1)	3	20.0	12	80.0	15	100	0	0	15	100	0	0
OXA-181 (n = 4)	ST17 (3), ST35 (1)	3	75	1	25	3	75	1	25	4	100	0	0
NDM-1 (n = 1)	ST101 (1)	0	0	1	100	0	0	1	100	0	0	1	100

^aOXA-48 group includes one OXA-48 + VIM-2-coproducing isolate.

^bKPC-3 group includes one KPC-3 + VIM-2-coproducing isolate.