Figure 3.

Histopathologic findings in Brugada syndrome. Myocardial tissue abnormalities associated with BrS are shown. Panel (A). Endomyocardial biopsy obtained from the right ventricle in a patient with genetically proven BrS shows lymphocytic inflammatory infiltrate with a CD3+ T-cell count consistent with myocarditis (immunohistochemistry assay—upper panel; hematoxylin-eosin assay—lower left panel; arrows). In the same patient, trichrome assay identifies areas of interstitial and replacement-type fibrosis, in blue color (lower right panel, arrows). Panel (B). Cardiac magnetic resonance obtained in the same patient before the automated cardioverter defibrillator implant shows abnormalities in parametric mapping involving the inferolateral left ventricular wall in both T1 and T2 sequences (n.v. for parametric mapping: T1 < 1045 ms; T2 < 50 ms). BrS = Brugada syndrome.