. 2022 Sep 28;13(10):1755. doi: 10.3390/genes13101755

Table 1.

Genetics of Brugada syndrome.

BrS Susceptibility Genes		Prevalence in BrS Cases	BrS Risk Loci	SNPs
SCN5A		20–25%	SCN5A	rs11708996
				rs7638909a
				rs62241190a
				rs7374540a
				rs7433206a
				rs34760424a
				rs41310232a
				rs6782237a
SCN10A		>5%	SCN10A	rs10428132
SCN10A		>5%	SCN10A	rs6801957
CACNA1C	CACNB2	1–2%	HEY2	rs9388451
CACNA1C	CACNB2	1–2%	HEY2	rs9398791
PKP2	HCN4	<1%	HDDC2	rs6913204a
KCNH2	KCNE3		HDDC2	rs6913204a
CACNA2D1	KCNJ8		TBX20	s11765936
KCND3	RANGFR		TBX20	rs340398a
SCN2B	SCN1B		GATA4	rs804281
KCND2	TRPM4		ZFPM2	rs72671655
KCNE5	ABCC9		WT1	rs72905083
SCN3B	SLMAP		TBX5	rs883079
FGF12	SEMA3A		IRX3	rs11645463
GPD1L			IRX5	rs72622262
References: [6,17,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43]			PRKCA	rs12945884
			MAPRE2	rs476348
			MYO18B	rs133902

The current knowledge about genetics in BrS is shown, including susceptibility genes, prevalence, risk loci, and polymorphisms. BrS = Brugada syndrome; SNPs = single nucleotide polymorphisms [6,17,21,22,23,24,25,26,27,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43].