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. 2022 Aug 22;10(5):e01076-22. doi: 10.1128/spectrum.01076-22

TABLE 1.

Biochemical indicators and routine blood indicator information of participants in different age groupsa

Category Variables 20 to 25 y (N = 17) 25 to 30 y (N = 33) 30 to 35 y (N = 36) ≥35 y (N = 48)
Biochemical indices Total protein (g/L) 63.05 ± 5.79 62.86 ± 6.41 60.88 ± 6.37 58.80 ± 6.84
Creatinine (μmol/L) 44.59 ± 6.53 42.6 ± 6.47 41.64 ± 6.45 46.26 ± 8.21
Total bilirubin (μmol/L) 8.48 ± 2.44 8.15 ± 3.98 8.69 ± 3.29 8.74 ± 3.29
Direct bilirubin (μmol/L) 1.45 ± 0.43 1.87 ± 2.66 1.3 ± 0.37 1.30 ± 0.48
Indirect bilirubin (μmol/L) 7.02 ± 1.37 6.26 ± 2.36 7.03 ± 1.82 6.91 ± 2.55
Albumin (g/L) 30.9 ± 2.403 31.08 ± 1.87 31.15 ± 2.97 29.40 ± 2.62
Globulin (g/L) 27.95 ± 2.89 28.47 ± 3.44 27.03 ± 3.32 26.27 ± 3.18
Ratio of albumin to globulin 1.11 ± 0.06 1.10 ± 0.12 1.16 ± 0.12 1.13 ± 0.14
Alanine transaminase (U/L) 17.47 ± 6.50 15 ± 7.16 14.27 ± 7.74 13.72 ± 7.31
Aspartate aminotransferase (U/L) 16.33 ± 2.66 16.39 ± 2.97 16.10 ± 2.57 16.94 ± 5.83
Alkaline phosphatase (U/L) 209.17 ± 84.83 195.67 ± 47.50 183.62 ± 59.52 184 ± 49.10
Gamma-glutamyl transferase (U/L) 10.83 ± 2.93 14.06 ± 10.26 11.43 ± 6.96 10.63 ± 4.70
Total bile acid (μmol/L) 3.78 ± 3.19 2.71 ± 1.72 2.50 ± 1.26 3.09 ± 2.65
Cholyglycine (μmol/L) 4.58 ± 0.88 4.39 ± 1.28 3.86 ± 0.51 4.33 ± 1.70
Fibronectin (mg/L) 186.83 ± 27.47 222.76 ± 28.57 212.62 ± 35.23 202.4 ± 33.94
Glycated hemoglobin (%) 5.34 ± 0.14 5.47 ± 0.28 5.54 ± 0.43 5.59 ± 0.32
Glucose (mmol/L) 5.38 ± 1.41 4.50 ± 1.05 4.58 ± 1.18 4.55 ± 1.07
Urea (mmol/L) 3.04 ± 0.81 3.03 ± 0.73 3.02 ± 0.89 3.16 ± 0.76
Retinol binding protein 40.83 ± 6.05 44.5 ± 4.67 42.5 ± 4.96 41.22 ± 5.57
β2 microglobulin (mg/L) 1.83 ± 0.1169 1.99 ± 0.22 1.86 ± 0.1376 1.99 ± 0.2978
Uric acid (μmol/L) 334.19 ± 98.61 322.74 ± 70.61 326.67 ± 86.38 327.82 ± 74.27
Triglyceride (mmol/L) 2.57 ± 0.90 2.69 ± 0.53 3.26 ± 1.36 3.57 ± 2.78
Total cholesterol (mmol/L) 6.29 ± 0.77 6.29 ± 1.24 6.22 ± 1.36 6.34 ± 1.52
High density lipoprotein cholesterol (mmol/L) 1.66 ± 0.40 1.74 ± 0.38 1.71 ± 0.37 1.63 ± 0.27
Low density lipoprotein cholesterol (mmol/L) 3.82 ± 0.85 3.42 ± 0.79 3.40 ± 1.12 3.50 ± 0.87
Non high density lipoprotein cholesterol (mmol/L) 4.63 ± 1.02 4.55 ± 0.94 4.52 ± 1.17 4.70 ± 1.33
Lipoprotein(a) (mg/dL) 20.67 ± 12.42 14.47 ± 10.57 15.86 ± 12.38 16.03 ± 11.26
Free fatty acid (μmol/L) 271.17 ± 84.38 338.76 ± 153.00 347.95 ± 119.05 362.53 ± 157.47
Homocysteine (μmol/L) 7.23 ± 2.64 7.35 ± 1.50 7.62 ± 3.23 7.35 ± 1.99
Hypersensitive C-reactive protein (mg/L) 1.85 ± 0.96 2.95 ± 1.76 4.68 ± 5.40 3.2 ± 2.14
K (mmol/L) 3.68 ± 0.30 3.80 ± 0.26 3.81 ± 0.21 3.78 ± 0.21
Na (mmol/L) 136.35 ± 1.17 136.33 ± 1.79 136.30 ± 1.65 136.40 ± 1.75
Cl (mmol/L) 105.35 ± 1.46 105 ± 2.53 105.64 ± 1.67 106.64 ± 5.05
P (mmol/L) 1.39 ± 0.16 1.23 ± 0.14 1.24 ± 0.16 1.24 ± 0.17
Ca (mmol/L) 2.18 ± 0.12 2.15 ± 0.10 2.15 ± 0.10 2.14 ± 0.13
Mg (mmol/L) 0.74 ± 0.05 0.78 ± 0.04 0.76 ± 0.04 0.77 ± 0.06
Fe (μmol/L) 8.67 ± 4.66 13.57 ± 6.62 12.19 ± 4.06 13.95 ± 12.71
Isoenzymes of creatine kinase (U/L) 8.33 ± 1.63 11.29 ± 4.81 9.86 ± 2.69 9.7 ± 5.55
Lactate dehydrogenase (U/L) 169.5 ± 16.45 180.47 ± 33.67 175.24 ± 34.67 180.8 ± 44.01
Amylase 83.64 ± 18.79 90.17 ± 18.32 90.33 ± 21.80 79.71 ± 17.77
Cholinesterase 5403.27 ± 695.85 5511.25 ± 762.20 5301 ± 762.80 5673.2 ± 763.94
Lactic 2.62 ± 1.13 2.58 ± 0.74 2.27 ± 0.51 2.21 ± 0.57
Serum amyloid A 4.16 ± 1.93 5.44 ± 2.17 10.83 ± 17.27 7.65 ± 7.85
Creatine Kinase (U/L) 39.82 ± 25.08 49.96 ± 28.16 58.53 ± 52.97 59.73 ± 90.75
Blood ammonia 18.13 ± 4.82 20 ± 6.93 17.18 ± 5.42 16.4 ± 6.52
Mass determination of creatine kinase isoenzyme 1.31 ± 0.65 1.92 ± 1.64 1.45 ± 0.65 1.59 ± 0.75
Procalcitonin determination 0.04 ± 0.02 0.038 ± 0.01 0.04 ± 0.03 0.04 ± 0.01
C-reactive protein 4.45 ± 3.99 2.9 ± 2.14 4.62 ± 5.37 3.52 ± 2.91
Vitamin D 27.07 ± 13.65 22.3 ± 13.83 27.01 ± 10.35 29.21 ± 8.94
Blood routine test indices White blood cell count (109/L)b 7.94 ± 2.30 8.94 ± 2.08 8.28 ± 1.95 7.37 ± 1.65
Absolute neutrophil count (109/L)b 5.94 ± 2.15 6.61 ± 1.72 6.03 ± 1.65 5.38 ± 1.48
Absolute value of monocytes (109/L)b 0.47 ± 0.14 0.65 ± 0.22 0.62 ± 0.20 0.50 ± 0.14
Platelet distribution width (fl)b 15.42 ± 2.04 15.03 ± 2.36 13.5 ± 2.51 14.77 ± 2.56
Percentage of neutrophils (%) 73.42 ± 6.75 73.53 ± 4.53 72.23 ± 5.25 72.1 ± 6.10
Percentage of lymphocytes (%) 19.5 ± 6.11 18.24 ± 4.04 19.00 ± 4.80 19.61 ± 5.15
Percentage of monocytes (%) 6.18 ± 1.51 7.21 ± 1.47 7.53 ± 1.91 6.99 ± 1.69
Percentage of eosinophils (%) 0.75 ± 0.74 0.86 ± 0.79 1.12 ± 1.05 1.18 ± 1.87
Percentage of basophilic granulocyte (%) 0.15 ± 0.09 0.15 ± 0.16 0.12 ± 0.11 0.12 ± 0.12
Absolute value of lymphocyte (109/L) 1.46 ± 0.32 1.58 ± 0.3693 1.52 ± 0.3498 1.40 ± 0.2782
Absolute value of eosinophils (109/L) 0.06 ± 0.07 0.08 ± 0.09 0.09 ± 0.09 0.08 ± 0.15
Red blood cell count (1012/L) 4.04 ± 0.24 4.06 ± 0.39 3.99 ± 0.33 3.99 ± 0.40
Hemoglobin (g/L) 120.94 ± 8.11 121.69 ± 10.37 119.86 ± 10.48 118.68 ± 13.95
Hematokrit (%) 36.59 ± 1.62 36.41 ± 2.97 35.71 ± 2.83 35.62 ± 3.72
Mean corpuscular vol (fl) 90.69 ± 5.14 90.20 ± 7.32 89.78 ± 5.34 89.64 ± 7.13
Mean corpuscular hemoglobin (pg) 29.96 ± 2.20 30.15 ± 2.62 30.13 ± 1.97 29.87 ± 2.81
Mean corpuscular hemoglobin concn (g/L) 330.29 ± 12.51 334.28 ± 11.88 335.5 ± 9.41 332.85 ± 12.74
Red blood cell distribution width (%) 13.84 ± 1.25 16.99 ± 9.66 14.37 ± 1.93 14.95 ± 4.89
Platelet count (109/L) 187.24 ± 31.04 195.56 ± 52.65 199.78 ± 45.40 185.09 ± 46.56
Thrombocytopenia (%) 0.18 ± 0.03 0.20 ± 0.05 0.20 ± 0.04 0.19 ± 0.04
Mean platelet vol (fl) 9.86 ± 0.98 10.26 ± 1.22 10.12 ± 0.94 10.53 ± 1.15
Platelet large cell ratio (%) 26.48 ± 6.88 28.42 ± 7.08 26.55 ± 6.50 29.96 ± 7.63
a

The P values were adjusted with the Benjamini-Hochberg correction.

b

Denotes adjusted P < 0.05.