Table 4.

Comparison of monkeypox clinical presentation and death rates with smallpox and chickenpox (adapted from [14]).

Characteristics	Monkeypox	Smallpox	Chickenpox
Virus	Monkeypox virus	Variola virus	Varicella-zoster virus
Fever	1–3 days before rash	1–3 days before rash	1–2 days before rash
Rash	Rash often in one stage of development; slow development; lesions denser on the face, and present on palms and soles	Rash often in one stage of development; slow development; lesions denser on the face and in mucous membranes of the nose and mouth, and present on palms and soles	Rash often in multiple stages of development; rapid development; lesions denser on the trunk and absent on palms and soles
Lymphadenopathy	Present	Absent	Absent
Death	Up to 10%	Up to 30%	Rare