Table 2.
Passive aortic mechanics immediately after 2, 4, and 6 mo post-ANG II
| Descending Thoracic Aorta-Fixed Pressure |
|||||||||
|---|---|---|---|---|---|---|---|---|---|
| C57BL/6 Ctrl (8 mo old) | 0 mo |
2 mo |
4 mo |
6 mo |
|||||
| Post-sham | Post-ANG II | Post-sham | Post-ANG II | Post-sham | Post-ANG II | Post-sham | Post-ANG II | ||
| N | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 |
| Unloaded dimensions | |||||||||
| Wall thickness, μm | 107 ± 3.9 | 112 ± 2.7 | 191 ± 4.6 | 110 ± 4.8 | 149 ± 12.8 | 117 ± 5.7 | 159 ± 7.4 | 124 ± 2.6 | 158 ± 10.4 |
| Outer diameter, μm | 956 ± 21 | 888 ± 9 | 1,142 ± 34 | 928 ± 15 | 1,089 ± 41 | 924 ± 19 | 1,006 ± 27 | 972 ± 17 | 1,031 ± 28 |
| Axial length, mm | 4.56 ± 0.25 | 4.93 ± 0.16 | 5.28 ± 0.22 | 5.78 ± 0.45 | 5.60 ± 0.34 | 5.21 ± 0.53 | 5.64 ± 0.45 | 6.64 ± 0.28 | 6.32 ± 0.48 |
| Loaded dimensions (pressure = 100) | |||||||||
| Outer diameter, μm | 1,422 ± 21.3 | 1,344 ± 11.7 | 1,358 ± 33.3 | 1,467 ± 21.2 | 1,506 ± 45.4 | 1,372 ± 28.2 | 1,386 ± 24.2 | 1,448 ± 36.2 | 1,405 ± 40.5 |
| Wall thickness, μm | 44 ± 1.9 | 41 ± 0.6 | 108 ± 6.9 | 41 ± 2.2 | 69 ± 7.2 | 44 ± 2.0 | 72 ± 4.8 | 51 ± 1.0 | 76 ± 5.4 |
| Inner radius, µm | 667 ± 10.9 | 631 ± 6.2 | 570 ± 18.4 | 692 ± 8.9 | 684 ± 24.3 | 642 ± 12.9 | 621 ± 11.4 | 673 ± 17.5 | 627 ± 21.5 |
| In vivo axial stretch (−) | 1.49 ± 0.01 | 1.64 ± 0.01 | 1.35 ± 0.02 | 1.53 ± 0.02 | 1.42 ± 0.01 | 1.61 ± 0.02 | 1.43 ± 0.03 | 1.48 ± 0.02 | 1.37 ± 0.02 |
| In vivo circumferential stretch (−) | 1.62 ± 0.02 | 1.68 ± 0.02 | 1.32 ± 0.04 | 1.74 ± 0.03 | 1.53 ± 0.05 | 1.65 ± 0.01 | 1.55 ± 0.02 | 1.65 ± 0.02 | 1.52 ± 0.03 |
| Systolic Cauchy stresses, kPa | |||||||||
| Circumferential | 202 ± 9.4 | 207 ± 4.4 | 72 ± 5.7 | 227 ± 10.2 | 140 ± 20.4 | 194 ± 7.3 | 117 ± 7.7 | 177 ± 3.8 | 113 ± 9.7 |
| Axial | 165 ± 8.2 | 223 ± 7.0 | 66 ± 7.1 | 201 ± 13.9 | 119 ± 16.8 | 184 ± 9.3 | 109 ± 10.3 | 156 ± 5.2 | 97 ± 9.7 |
| Systolic linearized stiffness, MPa | |||||||||
| Circumferential | 1.33 ± 0.01 | 1.28 ± 0.07 | 0.67 ± 0.03 | 1.45 ± 0.04 | 0.98 ± 0.28 | 1.30 ± 0.07 | 0.85 ± 0.05 | 1.36 ± 0.12 | 1.14 ± 0.18 |
| Axial | 1.29 ± 0.06 | 2.21 ± 0.06 | 0.98 ± 0.06 | 2.01 ± 0.08 | 1.34 ± 0.21 | 1.84 ± 0.20 | 1.26 ± 0.11 | 1.89 ± 0.14 | 1.25 ± 0.15 |
| Systolic stored energy, kPa | 48 ± 3.0 | 57 ± 2.0 | 12 ± 1.9 | 59 ± 4.3 | 31 ± 4.8 | 52 ± 2.5 | 26 ± 2.6 | 42 ± 1.2 | 23 ± 2.4 |
| Distensibility, 1/MPa | 20 ± 1.3 | 21.30 ± 1.01 | 13.41 ± 1.75 | 17.53 ± 1.09 | 15.98 ± 1.06 | 19.45 ± 1.81 | 17.70 ± 1.39 | 13.68 ± 0.75 | 10.77 ± 1.35 |
Values are means ± SE; n, number of mice/group.