Table 3.

Effect of R428 on passive mechanics 4 months after ANG II

	Descending Thoracic Aorta-Fixed Pressure (4 mo)
	Post-sham	Post-sham + R428	Post-ANG II	Post-ANG II + R428
N	5	5	5	5
Unloaded dimensions
Wall thickness, μm	117 ± 5.7	110 ± 1.8	159 ± 7.4	123 ± 4.4
Outer diameter, μm	924 ± 19	834 ± 49	1,006 ± 27	876 ± 57
Axial length, mm	5.21 ± 0.53	4.74 ± 0.31	5.64 ± 0.45	5.31 ± 0.49
Loaded dimensions (pressure = 100)
Outer diameter, μm	1,372 ± 28.2	1,183 ± 69.7	1,386 ± 24.2	1,236 ± 77.4
Wall thickness, μm	44 ± 2.0	48 ± 1.8	72 ± 4.8	54 ± 3.5
Inner radius, µm	642 ± 12.9	543 ± 34.8	621 ± 11.4	564 ± 38.0
In vivo axial stretch (−)	1.61 ± 0.02	1.46 ± 0.01	1.43 ± 0.03	1.46 ± 0.03
In vivo circumferential stretch (−)	1.65 ± 0.01	1.57 ± 0.03	1.55 ± 0.02	1.57 ± 0.03
Systolic Cauchy stresses, kPa
Circumferential	194 ± 7.3	151 ± 10.9	117 ± 7.7	141 ± 11.7
Axial	184 ± 9.3	165 ± 7.4	109 ± 10.3	147 ± 13.0
Systolic linearized stiffness, MPa
Circumferential	1.30 ± 0.07	1.18 ± 0.09	0.85 ± 0.05	1.06 ± 0.09
Axial	1.84 ± 0.20	2.00 ± 0.17	1.26 ± 0.11	1.89 ± 0.29
Systolic stored energy, kPa	52 ± 2.5	37 ± 2.6	26 ± 2.6	34 ± 3.9
Distensibility, 1/MPa	19.45 ± 1.81	15.76 ± 1.42	17.70 ± 1.39	16.50 ± 1.15

Values are means ± SE; n, number of mice/group.