FIG 5.

Amoxapine stimulates the killing of Mtb in vivo. Mtb burden in the lungs of BALB/c mice (A) was enumerated at 2 weeks ad libitum treatment with Amoxapine or DMSO after intranasal infection with ~100 CFU H37Rv. A nonparametric unpaired t test was used to determine significant differences between the Amoxapine-treated and control DMSO groups. (B) Mtb burden in the lungs of C57BL/6 mice was enumerated at 2 weeks ad libitum treatment with Amoxapine or DMSO after intranasal infection with ~860 CFU H37Rv. A nonparametric (Kruskal-Wallis) test with Dunn’s post hoc test was used to compare drug-treated groups to the control DMSO group. (C) Representative hematoxylin and eosin (H&E)-stained lung sections at 2 weeks post-treatment with Amoxapine or vehicle control DMSO, as described in panel A. *, P < 0.05.