Table 1.
Hypothesis estimates based on results from studies using ACE Q scores.
| Outcome | References, CI | Estimates, RR | ||
|---|---|---|---|---|
| 1 ACE | >4 ACE | Low Adversity | Severe Adversity | |
| Cardiovascular disease | 0.95–1.24 | 0.91–2.06 | 1 | 2.5–3.0 |
| Cancer | 0.83–1.63 | 0.57–2.20 | 1 | 2.0–2.5 |
| Obesity | 0.99–1.42 | 0.85–2.34 | 1 | 1.2 |
| Depression | 1.51–1.72 | 2.14–5.03 | 1.5 | 2.5–3.0 |
| Anxiety | 1.17–1.77 | 2.19–2.98 | 1.2–1.4 | 2.5–3.0 |
| Daily Smoking | 1.19–1.38 | 1.71–2.18 | 1.2 | 1.9–2.1 |
| Alcohol Addiction | 1.22–1.87 | 1.13–3.95 | 1.2–1.5 | 1.8–2.1 |
CI resembles the lowest and highest CI from the included studies in this analysis. Abbreviations: CI = Confidence Interval; RR = Risk Ratio. Low adversity equals 1 adversity on the ACE score. Severe adversities equal ≥ 4 adversities on the ACE score.