Figure 4.

The baseline expression of NLRP3 inflammasome pathway components in primary human pDCs. The NLRP3, ASC, pro-caspase-1, cleaved caspase-1, pro-IL-1β and cleaved IL-1β expressions in primary human pDCs gated from PBMCs were measured using intracellular flow cytometry. Representative dot plots are shown in (A). Green dots indicate isotype controls and red dots show the specific proteins (A). Data are represented as mean ± SD of 22 individual experiments and analyzed using one-way ANOVA followed by Bonferroni’s post-hoc test (B). SSC: side scatter.