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AZD5634 does not significantly alter functional anatomy in Cftr−-/− rat trachea and lungs in situ. Airway surface liquid (ASL) depth (A), mucociliary transport (MCT) rate (B), and ciliary beat frequency (CBF; C) as determined by µOCT analysis of trachea and lungs excised en bloc from Cftr−-/− rats treated with AZD5634 or vehicle control. n = 8 animals per group. Means ± SE.
