Figure 2.

SCP2/SCPx function in the transport and metabolism of cholesterol and other lipids. SCP2/SCPx may transport cholesterol between various cellular membranes and organelles, such as the plasma membrane, mitochondria, lipid droplets, ER, lysosomes, and peroxisomes. Cholesterol intermediates also undergo oxidation in peroxisomes via SCPx for bile acid synthesis. In addition to cholesterol transport, SCP2/SCPx play a role in fatty acid, phospholipid, and sphingolipid transport. SCPx is also a key enzyme in the peroxisomal β-oxidation of fatty acids. Abbreviations: Ch: cholesterol; ER: endoplasmic reticulum.