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. 2022 Sep 15;133(5):1055–1066. doi: 10.1152/japplphysiol.00035.2022

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Figure 3. — Effect of AMP deaminase 1 (AMDP1) knockdown on EDL contractile characteristics during fatiguing contractions. Inhibitory microRNA (RNAi) knockdown of AMPD1 had no effect on force loss during the 5-min protocols of LOW (A), MOD (B), or HIGH fatigue (C). RNAi slowed time-to-peak tension (TPT) during LOW (D), MOD (E), and HIGH (F). Furthermore, RNAi impaired half-relaxation time (½ RT) during LOW (G), MOD (H), and HIGH (I). *P < 0.05 main effect of treatment (RNAi) by ANOVA. Data are represented as means ± SD, n = 10–12 males and 5 or 6 females per group.