TABLE 1.
Gene mutation analysis, MIC of colistin, and LAL assay results for representative colistin-resistant A. baumannii strains
| Mutated gene | Strain | Mutation | Colistin MIC (μg/mL) | Endotoxin concn (EU/mL)a |
|---|---|---|---|---|
| None (wild type) | ATCC 19606 | 2 | 9.2 × 103 ± 6.0 × 103 | |
| lpxA | KL001S | 591_592delTA: I198fs(I198*) | 128 | <0.1 |
| lpxC | KL037S | 475_689(215)del: D159fs(D159C)D161* | 128 | <0.1 |
| lpxD | KL055S | 218insA: D75fs(D75R)N76* | 128 | <0.1 |
| pmrA | CM022S | 36G>T: M12I | 1024 | 17 × 103 ± 8.7 × 103 |
| pmrB | CM012S | 697C>T: P233S | 1024 | 13 × 103 ± 9.8 × 103 |
a
Determined by the LAL assay at an OD of 0.1. EU, endotoxin units. Values are means ± SD.