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. 2022 Aug 24;10(5):e01056-22. doi: 10.1128/spectrum.01056-22

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Copyright © 2022 Huang et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 3 — A PKCδ inhibitor impairs the replication of the SARS-CoV-2 replicon. (A and B) IC₅₀s of rottlerin in BHK-21 (A) and human Huh7 (B) cells. IC₅₀ values are indicated above the curves. (C and D) CC₅₀s of rottlerin in BHK-21 (C) and human Huh7 (D) cells. The cytotoxic effects of each drug at the indicated concentrations were determined by a CCK8 cell viability assay at 24 h. CC₅₀ values were calculated using Prism software and are indicated above the curves. Data are presented as means ± SD from three experiments.