TABLE 2.

Correlations among differential bacteria, differential fecal metabolites, and annotated human metabolic pathways

Differential metabolite	Metabolite change	Differential microbiota member	Microbiota member change	Rho	Correlation P value	Human pathway annotation(s)
Acetylcholine	↑	Bilophila	↓	−0.396	0.013	Cholinergic synapse
		Plesiomonas	↑	0.353	0.027
		Ramlibacter	↑	0.329	0.041
d-Glucuronic acid	↓	Weissella	↑	−0.418	0.008	Pentose and glucuronate interconversions
		Plesiomonas	↑	−0.372	0.019
		HIMB11	↑	−0.340	0.034
		Finegoldia	↑	−0.327	0.042
		Coriobacteriaceae_UCG-002	↓	0.509	0.0009
Citrulline	↓	Holdemanella	↑	−0.407	0.010	Arginine biosynthesis
l-Lysine	↓	Ruminococcaceae_UCG-008	↑	−0.449	0.004	Protein digestion and absorption, aminoacyl-tRNA biosynthesis, lysine degradation
		Holdemanella	↑	−0.364	0.023
		Bacteroides	↓	0.334	0.038
l-Proline	↓	Ruminococcaceae_UCG-008	↑	−0.359	0.025	Protein digestion and absorption, aminoacyl-tRNA biosynthesis
		Holdemanella	↑	−0.396	0.013
		Bacteroides	↓	0.339	0.035
		Ruminococcaceae_UCG-007	↓	0.352	0.028
2-Hydroxycinnamic acid	↓	Ruminococcaceae_UCG-008	↑	−0.494	0.001	Phenylalanine metabolism
		Holdemanella	↑	−0.534	0.0005
		Tyzzerella_3	↑	−0.354	0.027
		Bacteroides	↓	0.372	0.020
		Faecalitalea	↓	0.345	0.031
		Erysipelatoclostridium	↓	0.412	0.009