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. 2022 Oct 12;23(20):12170. doi: 10.3390/ijms232012170

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Transcriptional changes in MAPK-pathway related genes. Heatmap showing genes related to the MAPK gene set (MSigDB, gene set enrichment analysis) differentially expressed between wild−type and rd1 rod and cone photoreceptors (p-value ≤ 0.5; |avg_log2FC| > 0.3) for the post-natal (P) day 11, P13, and P17 time−points. Blue indicates downregulated genes, red indicates upregulation. A total of 46 MAPK pathway genes were significantly altered in rods, whereas six genes were altered in cones.