. 2022 Oct 12;23(20):12149. doi: 10.3390/ijms232012149

Table 6.

The results of the toxicity test with ProToxII.

S/N	Comp Code	LD₅₀ mg/kg	Toxici-ty Class	Average Similarity	Prediction Accuracy %	Hepatotoxicity	Carcino-Genicity	Immuno-Toxicity	Muta-Genicity	Cytotoxicity	Aroma-Tase	Estrogen Receptor-α	Androgen Receptor	PPAR-γ
1	HPS/001	5000	V	61.43	68.07	Inactive ^a	Inactive ^a	Inactive ^a	Inactive ^a	Inactive ^a	Inactive ^a	Inactive ^a	Inactive ^a	Inactive ^a
2	HPS/002	5000	V	58.87	67.38	Inactive ^a	Inactive ^a	Inactive ^a	Inactive ^a	Inactive ^a	Inactive ^a	Inactive ^a	Inactive ^a	Inactive ^a
3	HPS/003	5000	V	61.99	68.07	Inactive ^a	Inactive	Inactive ^a	Inactive ^a	Inactive ^a	Inactive ^a	Inactive ^a	Inactive ^a	Inactive ^a
4	HPS/004	5000	V	58.87	67.38	Inactive ^a	Inactive ^a	Inactive ^a	Inactive ^a	Inactive ^a	Inactive ^a	Inactive ^a	Inactive ^a	Inactive ^a
5	Lopinavir	5000	V	59.88	67.38	Inactive ^a	Inactive ^a	Inactive ^a	Inactive ^a	Inactive ^a	Inactive ^a	Inactive ^a	Inactive ^a	Inactive ^a
6	HPS/005	1000	IV	40.75	54.26	Active	Inactive	Inactive	Inactive	Inactive	Inactive ^a	Inactive ^a	Inactive ^a	Inactive ^a
7	HPS/006	800	IV	42.36	54.26	Inactive	Inactive	Inactive ^a	Inactive	Inactive	Inactive ^a	Inactive ^a	Inactive ^a	Inactive ^a
8	HPS/007	1000	IV	42.53	54.26	Inactive	Inactive	Inactive ^a	Inactive	Inactive	Inactive ^a	Inactive ^a	Inactive ^a	Inactive ^a
9	HPS/008	500	IV	40.28	54.26	Inactive	Inactive	Inactive ^a	Inactive	Inactive	Inactive ^a	Inactive ^a	Inactive ^a	Inactive ^a
10	Ritonavir	1000	IV	42.32	54.26	Active ^a	Inactive	Inactive ^a	Inactive ^a	Inactive	Inactive ^a	Inactive ^a	Inactive ^a	Inactive ^a
11	HPS/009	300	III	48.58	54.26	Inactive	Inactive	Inactive ^a	Inactive ^a	Inactive	Inactive ^a	Inactive ^a	Inactive ^a	Inactive ^a
12	HPS/010	300	III	48.58	54.26	Inactive ^a	Inactive	Inactive ^a	Inactive ^a	Inactive	Inactive ^a	Inactive ^a	Inactive ^a	Inactive ^a
13	HPS/011	300	III	48.58	54.26	Inactive ^a	Inactive	Inactive ^a	Inactive ^a	Inactive	Inactive ^a	Inactive ^a	Inactive ^a	Inactive ^a
14	HPS/012	300	III	48.12	54.26	Inactive	Inactive	Inactive ^a	Inactive ^a	Inactive	Inactive ^a	Inactive ^a	Inactive ^a	Inactive ^a
15	Fosamprenavir	300	III	43.99	54.26	Inactive ^a	Inactive	Inactive ^a	Inactive	Inactive	Inactive ^a	Inactive ^a	Inactive ^a	Inactive ^a
16	HPS/013	300	III	50.25	67.38	Inactive ^a	Inactive	Inactive ^a	Inactive ^a	Inactive	Inactive ^a	Inactive ^a	Inactive ^a	Inactive ^a
17	HPS/014	300	III	50.25	67.38	Inactive ^a	Inactive	Inactive ^a	Inactive ^a	Inactive	Inactive ^a	Inactive ^a	Inactive ^a	Inactive ^a
18	HPS/015	2500	V	51.48	67.38	Inactive	Inactive	Inactive ^a	Inactive ^a	Inactive	Inactive ^a	Inactive ^a	Inactive ^a	Inactive ^a
19	HPS/016	1000	IV	48.28	54.26	Inactive ^a	Inactive	Inactive ^a	Inactive ^a	Inactive	Inactive ^a	Inactive ^a	Inactive ^a	Inactive ^a
20	Amprenavir	300	III	48.58	54.26	Inactive ^a	Inactive	Inactive ^a	Inactive ^a	Inactive	Inactive ^a	Inactive ^a	Inactive ^a	Inactive ^a
21	HPS/017	200	III	47.45	54.26	Active	Active	Active ^a	Inactive	Inactive	Inactive ^a	Inactive ^a	Inactive ^a	Inactive ^a
22	HPS/018	200	III	44.60	54.26	Inactive	Inactive	Inactive ^a	Inactive	Inactive	Inactive ^a	Inactive ^a	Inactive ^a	Inactive ^a
23	HPS/019	500	IV	60.36	68.07	Inactive	Inactive	Inactive ^a	Inactive ^a	Inactive	Inactive ^a	Inactive ^a	Inactive ^a	Inactive ^a
24	HPS/020	200	III	48.94	54.26	Inactive	Inactive	Inactive ^a	Inactive	Inactive	Inactive ^a	Inactive ^a	Inactive ^a	Inactive ^a
25	Atazanavir	200	III	47.65	54.26	Active	Inactive	Inactive ^a	Inactive	Inactive	Inactive ^a	Inactive ^a	Inactive ^a	Inactive ^a
26	HPS/021	245	III	48.68	54.26	Active	Inactive	Active	Inactive	Inactive	Inactive ^a	Inactive ^a	Inactive ^a	Inactive ^a
27	HPS/022	245	III	48	54.26	Active	Inactive	Active	Inactive	Inactive	Inactive ^a	Inactive ^a	Inactive ^a	Inactive ^a
28	HPS/023	245	III	50.43	67.38	Active	Active	Active	Inactive	Inactive	Inactive ^a	Inactive ^a	Inactive ^a	Inactive ^a
29	HPS/024	3000	V	47.04	54.26	Active	Inactive	Inactive ^a	Inactive	Inactive	Inactive ^a	Inactive ^a	Inactive ^a	Inactive ^a
30	Darunavir	245	III	52.42	67.38	Active ^a	Inactive	Inactive	Inactive	Inactive	Inactive ^a	Inactive ^a	Inactive ^a	Inactive ^a
31	HPS/025	1000	IV	45.27	54.26	Inactive	Inactive	Active ^a	Inactive	Inactive	Inactive ^a	Inactive ^a	Inactive ^a	Inactive ^a
32	HPS/026	1000	IV	43.19	54.26	Inactive	Inactive	Active ^a	Inactive	Inactive	Inactive ^a	Inactive ^a	Inactive ^a	Inactive ^a
33	HPS/027	1000	IV	43.19	54.26	Inactive	Inactive	Active ^a	Inactive	Inactive	Inactive ^a	Inactive ^a	Inactive ^a	Inactive ^a
34	HPS/028	1000	IV	45.52	54.26	Inactive	Inactive	Active ^a	Inactive ^a	Inactive	Inactive ^a	Inactive ^a	Inactive ^a	Inactive ^a
35	Nelfinavir	600	IV	49.30	54.26	Inactive	Inactive	Active ^a	Inactive ^a	Inactive	Inactive ^a	Inactive ^a	Inactive ^a	Inactive ^a

^a High probability (≥0.70); Peroxisome Proliferator Activated Receptor Gamma (PPAR-Gamma).