Table 1.

Deregulated miRNAs identified comparing D842V vs. non-D842V GIST patients.

miRNA ID	Delta Ct	D842V vs. Non-D842V	p-Value	Predicted Targets among the Deregulated Gene in Our Cohort of Patients *
hsa-miR-1825	−5.31	↑	0.027	NLK(2)
hsa-miR-431-3p	−4.96	↑	0.009
hsa-miR-20b-3p	−3.87	↑	0.015
hsa-miR-149-3p	−3.40	↑	0.037	SPRY4(2)
hsa-miR-9-5p	−2.98	↑	0.038	GNPNAT1(2), SIRT1(3), CREB5(2), POU2F1(3), BCL6(3), PXDN(3), RNF169(2), FBN2(3), PTAR1(2), NIN(2)
hsa-miR-604	−2.82	↑	0.044
hsa-miR-661	−1.64	↑	0.049	IL17RA(2)
hsa-miR-133b	−1.43	↑	0.032	PPP2R2D(2), SP1(2), ZHX3(2), CREB5(2),
hsa-miR-133a-3p	−1.38	↑	0.044
hsa-miR-1233-3p	−1.07	↑	0.042
hsa-miR-545-3p	1.32	↓	0.048	TSPAN2(2)
hsa-miR-210-3p	1.56	↓	0.046	NPTX1(1)
hsa-miR-221-3p	1.59	↓	0.039
hsa-miR-135b-5p	2.10	↓	0.027
hsa-miR-33a-5p	2.12	↓	0.043
hsa-miR-452-5p	2.18	↓	0.044
hsa-miR-219a-5p	2.43	↓	0.019
hsa-miR-499a-5p	2.72	↓	0.017
hsa-miR-517c-3p	2.79	↓	0.024
hsa-miR-873-5p	3.07	↓	0.027
hsa-miR-512-3p	3.60	↓	0.032
hsa-miR-708-5p	3.92	↓	0.002
hsa-miR-122-5p	4.45	↓	0.010	CD320(2)
hsa-miR-15a-5p	6.43	↓	0.025	RSPO3(2)

↑: up-regulation; ↓: down-regulation; * in brackets: number of in silico tools predicting the same target which was also deregulated in previous gene expression analysis see ref. [21].