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WYBQ-4 exhibits excellent safety. (A) The hemolytic activity assay revealed that different concentrations of WYBQ-4 did not destroy erythrocytes in rabbits and goats, and (B) the absorbance of the supernatant was measured at 543 nm. (C) The acute toxicity test showed that intraperitoneal injection of WYBQ-4 (300 mg/kg) did not affect the survival of the mice. (D to F) WYBQ-4 (0-128 μg/mL) did not affect the viability of A549, HEK-293T and HepG2 cells.
