FIG 5.

WYBQ-4 protects mice from S. aureus-induced pneumonia. (A and B) Scheme of (A) survival and (B) lung tissue and bacterial load in a mouse pneumonia infection model. (C) Effect of WYBQ-4 and ceftaroline fosamil treatment on the survival of mice (n = 10) infected with a lethal dose of S. aureus within 72 h. Log-rank test; NS, no significant difference (P > 0.05). (D) Effect of WYBQ-4 treatment on the bacterial load in the lungs of mice (n = 4). ***, P < 0.001 versus the WT group; Mann-Whitney test, two-tailed. (E) Histopathology of the lungs (H&E stained) of mice treated with or without WYBQ-4. Scale bar = 50 μm.