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. 2022 Sep 13;10(5):e00547-22. doi: 10.1128/spectrum.00547-22

FIG 6.

FIG 6

WYBQ-4 protects mice from S. aureus-induced intramuscular infection. (A) Experimental protocol for the mouse intramuscular infection model. (B and C) Effects of (B) WYBQ-4 (300 and 75 mg/kg) and moxalactam (300 and 75 mg/kg) on the bacterial load of MRSA USA300 and (C) MSSA 229213 on the thighs of mice. (D and E) Effect of (D) WYBQ-4 (75 and 37.5 mg/kg) and ceftaroline fosamil (75 and 37.5 mg/kg) on the bacterial load of MRSA USA300 and (E) MSSA 229213 on the thighs of mice. NS, no significant difference (P > 0.05), ***, P < 0.001 versus the WT group. Mann-Whitney test, two-tailed.